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Integratori per la menopausa: donna con le braccia sollevate
Home / Magazine / R&D Innovation / Supplements for menopause: Biofarma Group’s R&D laboratories to support women’s well-being
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Supplements for menopause: Biofarma Group’s R&D laboratories to support women’s well-being

Data: 22_03_2023
Category: R&D Innovation

Women, throughout their lives, go through different phases, each of which is important and characterized by specific and diversified needs in terms of health.

Menopause, in particular, marking the end of fertility, represents a very delicate period that is experienced and faced differently by each woman but which has as its common denominator a greater physical and psychological vulnerability.

For this reason, women must be accompanied and supported in this physiological phase. Often, real help comes from food supplements for menopause, which help manage all the effects of this condition. 

Menopause supplements: why is it essential to take them?

The woman’s entry into menopause generally occurs between 46 and 55 years and is indicated by 12 consecutive months of absence of the menstrual cycle. This transition does not happen suddenly but follows a gradual process that can vary from a few months to a few years, in which there is a progressive decline in ovarian function and the manifestation of signs that it is essential to be able to recognize and that may consist of alterations in menstrual rhythm, a worsening of premenstrual symptoms and the appearance of hot flashes, sleep, and mood disorders.

Integratori per la menopausa: elenco dei sintomi che possono combattere

The actual menopause is instead characterized by numerous symptoms that are generally highly variable and therefore experienced differently. Specifically, menopausal women may have the following:

  • Vasomotor disorders: hot flashes accompanied by sweating and tachycardia (day and night).

  • Sleep disorders

  • Psychic disorders: anxiety, irritability, difficulty concentrating, and mood swings

  • Uro-gynecological disorders: dryness, reduced vaginal elasticity, increased sensitivity to infections (cystitis), and urination disorders

  • Disorders of sexuality

  • Muscle and osteoarticular pain

  • Increased body weight

  • Trophic alterations of skin and appendages: thinning and increasing dryness of the skin, thinning of hair, and, sometimes, hair loss

Several remedies can help women face, and sometimes even prevent, these multiple symptoms. First, it is essential to follow a healthy lifestyle through a correct and balanced diet and regular physical activity that improves sleep quality and mood, reducing cardiovascular risk and osteoporosis. In addition, it is important to emphasize that smoking and excessive consumption of alcoholic beverages contribute to a drastic worsening of menopausal symptoms.

However, external help is often needed to counteract the various disorders related to the condition. In this context, a significant benefit, as already mentioned, is represented by the intake of menopause supplements, as they contain substances that are useful to counteract the effects of age and hormonal deficit, acting at a metabolic level and reducing symptoms.

These products are particularly suitable for those women who do not have severe symptoms and represent a natural remedy in menopause, able not only to counteract disorders that can compromise the quality of life but also to contribute to the general well-being of those who take them.

From Biofarma Group, two innovative menopause treatments

Women’s health and well-being have always been among Biofarma Group’s therapeutic targets. Its research and development laboratories have created a range of formulations able to accompany all the physiological phases women go through during their lives, considering specific needs and problems.

Within this range of formulations emerge two menopause treatments that can provide concrete support to women facing this condition: we are talking about T-Win Menopause and ODT Woman Well-being.

Elenco ingredienti T-win Menopausa, integratore per donne in menopausa

T-Win menopause is an innovative menopause supplement composed of a synergistic mix of natural elements, each of which can help counteract specific problems related to the condition. The components of the product are bifidobacterium lactis, vitamin D, calcium, magnesium, and sage.

B-Lactis is a strain of bifidobacteria (Bifidus) that belongs to the family of lactic acid bacteria. The probiotic formulation used in this nutraceutical has been subjected to clinical tests that have shown its effectiveness in reducing fat mass and abdomen volume, one of the main problems related to menopause, as well as an ability to strengthen good intestinal bacteria linked to the well-being of metabolism, reducing hence the risk of weight-related health problems.

Vitamin D deficiency, often present in menopausal women, is associated with increased metabolic syndrome, high triglyceride levels, and low levels of high-density lipoprotein cholesterol. Its integration can therefore help solve these problems and contribute to the general improvement of the organism’s health. Numerous studies have also shown that its intake and calcium play an essential role in preventing and managing osteoporosis in women of advanced age, thus promoting bone health, and reducing the risk of fractures.

Magnesium, on the other hand, has shown essential benefits in counteracting hot flashes: this is a significant effect considering that it is a symptom that appears in 90% of menopausal women and can lead to consequences that are difficult to manage, such as reducing the quality of sleep.

Finally, numerous studies have shown the effects of sage on several disorders that affect post-menopausal women. Specifically, the sage extract has demonstrated the ability to reduce hot flashes and night sweats, but also beneficial effects in managing anxiety and depressive states.

This synergistic mix of ingredients is contained in an innovative packaging: the T-Win system. It is a sachet composed of two chambers that allow you to pack different but miscible powders to be kept separate until intake. The advantages are numerous: starting from the practicality of use and the better experience of taking components with an unpleasant taste, obtained thanks to effervescence, up to the ability to guarantee excellent product stability and increase the solubility of water-insoluble components.

The ODT Woman Well-being product, on the other hand, is helpful in case of menopause, but not only. The formulation aims to guarantee and support women’s health at 360 degrees. It is a tablet that can counteract the main female discomforts and support daily well-being, ensuring harmony and vitality, especially in crucial moments such as menstruation, pregnancy, breastfeeding, menopause, and generalized fatigue.

elenco ingredienti ODT Woman Well Being, integratore per donne in menopausa

These effects are made possible by its two main components: folic acid and iron.

A prolonged iron deficiency can lead to apathy, listlessness, lack of energy, cognitive impairment, affective decline, difficulty concentrating, mood-related disorders (irritability and tachycardia), and sleep disorders.

That is why it is important to opt for iron supplementation. For this formulation, a trademarked microencapsulated and micronized liposomal iron was used. Various studies have shown that the microencapsulated form has the great advantage (compared to the formulation of iron in ionic form) of high absorption and high bioavailability in the face of reduced systemic toxicity (Visciano et al., Giornale Italiano di Nefrologia, 2013). Furthermore, thanks to liposomal microencapsulation technology, the metallic taste typical of iron is also eliminated, and it is, therefore, possible to obtain a tablet of a pleasant flavor.

Folic acid, on the other hand, is essential to counteract anemia and cognitive functions. In addition, it contributes to the regular activity of psychological processes, such as resistance to stress and the reduction of fatigue.

Also, in the case of this product, a particularly innovative pharmaceutical form has been selected: the oral disintegration tablet (ODT). It is a dosing technology that disintegrates quickly, without adding water, when inserted into the oral cavity. The active ingredients are then absorbed into the bloodstream by the oromucosal cavity.

This pharmaceutical form has advantages over the traditional tablet because it bypasses hepatic metabolism: a more significant part of the drug is absorbed into the systemic circulation, leading to greater bioavailability and therapeutic efficacy.

 

Edited by:

  • Stefania Murzilli: Scientific Specialist

  • Valentina Milite: R&D Food Supplement

 

Bibliography

  • Orthmann N., “Benessere in menopausa. Il vademecum di O.N.Da”.

  • SimaKiani Rad, Sedighe Forouhari, Alamtaj Samsami Dehaghani, Homeira Vafaei, Mehrab Sayadi, Maryam Asadi, “The effect of salvia officinalis tablet on hot flashes, night sweating, and estradiol hormone in postmenopausal women”, International Journal of Medical Research & Health Sciences, 2016, 5, 8:257-263.

  • Naeimeh Tayebi, Masoumeh Emamghoreishi, Marzieh Akbarzadeh, “The Impact of Salvia officinalis Extract on Depression in Postmenopausal Women: A Randomized Clinical Tria”, International Journal of Women’s Health and Reproduction Sciences Vol. 9, No. 4, October 2021, x–x.

  • Fereshteh Dadfar, Kourosh Bamdad, “The effect of Saliva officinalis extract on the menopausal symptoms in postmenopausal women: An RCT”.

  • Faustino R. Pérez-López , Peter Chedraui, Stefan Pil “Vitamin D supplementation after the menopause”, Ther Adv Endocrinol Metab 2020, Vol. 11: 1–13.

  • Boonen, D. Vanderschueren, P. Haentjens, P. Lips, “Calcium and vitamin D in the prevention and treatment of osteoporosis – a clinical update”, Journal of Internal Medicine 2006; 259: 539–552.

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